bactrim and tattoos

Treatment of MRSA at home usually includes a 7- to 10-day course of an antibiotic (by mouth) such as trimethoprim-sulfamethoxazole (brand name: Bactrim), clindamycin, minocycline, linezolid, or doxycycline. 7 Things You Should Avoid If You Have G6PD Deficiency. Anecdotally, some people have reported unusual skin reactions to tattoos when they were on antibiotics. Federal government websites often end in .gov or .mil. Hey guys, Does anybody have experience with taking Bactrim and getting a tattoo? Tell your doctor if you have diarrhea that is watery or bloody. Seven key questions to consider. Yes, people still use mothballs, mainly to get rid of moths and other insects. Acidification of the urine will increase renal elimination of trimethoprim. All rights reserved. See additional information. BACTRIM is available as an injection containing 80 mg/mL of sulfamethoxazole and 16 mg/mL of trimethoprim in 10 mL single-dose and 30 mL multiple-dose vials. Monitor patients for hematologic toxicity. Is Aquaphor Recommended After Getting a Tattoo? extreme thirst. 4. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. (n.d.), statista.com/chart/9980/us-adults-with-a-tattoo/, fda.gov/consumers/consumer-updates/tattoo-you-seven-key-questions-consider, smithsonianmag.com/smart-news/how-common-are-infections-from-tattoo-ink-32664291/, ouh.nhs.uk/patient-guide/leaflets/files/33184Pmicropigmentation.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC4411590/, diseasedaily.org/diseasedaily/article/cdc-links-rare-bacterial-infection-tattoos-81211, cdc.gov/mmwr/preview/mmwrhtml/mm5524a3.htm, dermnetnz.org/topics/tattoo-associated-skin-reactions/, prnewswire.com/news-releases/one-in-five-us-adults-now-has-a-tattoo-140123523.html, health.harvard.edu/blog/tattoos-and-infection-think-before-you-ink-201210125405, cdc.gov/mmwr/preview/mmwrhtml/mm6133a3.htm, blogs.cdc.gov/publichealthmatters/2012/08/the-hidden-dangers-of-getting-inked/, fda.gov/consumers/consumer-updates/think-you-ink-are-tattoos-safe, patient.uwhealth.org/education/after-care-instructions-for-permanent-tattooing.html, Help! Honesty, though, is always the best policy. Quinolones, including Cipro and Levaquin. LEARN ABOUT BYRDIE'S EDITORIAL GUIDELINES, Universal precautions for preventing transmission of bloodborne infections, 6 Months or Less Postpartum or Post-Weaning. All rights reserved. Tattoo-associated skin reactions. A hemolytic crisis is when your body destroys red blood cells faster than it can make new ones. Occasional reports suggest that patients receiving pyrimethamine as malaria prophylaxis in doses exceeding 25 mg weekly may develop megaloblastic anemia if BACTRIM is prescribed. Did you know that favism is another term for G6PD deficiency, especially in severe cases? But if these symptoms continue for a week or more, see your tattoo artist or doctor. Elderly people may be more susceptible to the side effects of Bactrim. If youre experiencing an infection, treatment depends on the cause. Even treatment with recommended doses may cause hyperkalemia when trimethoprim is administered to patients with underlying disorders of potassium metabolism, with renal insufficiency, or if drugs known to induce hyperkalemia are given concomitantly. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Complete blood counts should be done frequently in patients receiving sulfonamides. other information we have about you. BACTRIM is indicated in the treatment of severe or complicated urinary tract infections in adults and pediatric patients two months of age and older due to susceptible strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris when oral administration of BACTRIM is not feasible and when the organism is not susceptible to single-agent antibacterials effective in the urinary tract. In total remission but bactrim was still a daily thing. May lower blood sugar levels in people without diabetes. Transformations: After-care instructions for permanent tattooing. This content does not have an English version. J Infect Dis. J Pediatr Pharmacol Ther. Children 2 months of age and olderDose is based on body size and must be determined by your doctor. Localized cutaneous infections in immunocompetent individuals due to rapidly growing mycobacteria. The overall prevalence of sulfite sensitivity in the general population is unknown. In those instances where fluid restriction is desirable, each 5 mL may be added to 75 mL of 5% dextrose in water. methicillin-resistant Staphylococcus aureus, Total Daily Dose (based on trimethoprim content), 15-20 mg/kg (in 3 or 4 equally divided doses), 8-10 mg/kg (in 2 to 4 equally divided doses). In in vitro and in vivo tests in animal species, sulfamethoxazole/trimethoprim did not damage chromosomes. Bactrim is available as a generic under the name sulfamethoxazole/trimethoprim. Tattoo infections are usually easy to treat and even easier to prevent. Follow your doctor's orders or the directions on the label. Clinical signs, such as rash, sore throat, fever, arthralgia, cough, shortness of breath, pallor, purpura or jaundice may be early indications of serious reactions. Cutaneous infection with Mycobacterium fortuitum after localized microinjections (mesotherapy) treated successfully with a triple drug regimen. Yes, Bactrim DS contains sulfamethoxazole and trimethoprim. Yet several antibiotics can cause red blood cells to break down. In glucose-6-phosphate dehydrogenase deficient individuals, hemolysis may occur. However, keep in mind that it may be difficult to know what exactly is in tattoo inks as they arent regulated in any way. 2. Should not be used in pregnant or lactating women or babies less than two months old. official website and that any information you provide is encrypted This medicine is available only with your doctor's prescription. 7 Things You Should Avoid If You Have G6PD Deficiency - Verywell Health At least 90 percent of the following bacteria exhibit an in vitro minimum inhibitory concentration (MIC) less than or equal to the susceptible breakpoint for BACTRIM against isolates of similar genus or organism group. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Pharmacokinetic values for sulfamethoxazole in geriatric subjects were similar to those observed in young adult subjects. Blood dyscrasias and jaundice are potential late manifestations of overdosage. Patients who are slow acetylators may be more prone to idiosyncratic reactions to sulfonamides. Aspirin is often used to treat pain or inflammation. Weighing 30 kg3 teaspoonfuls (15 mL) of oral liquid or 1 tablet 2 times a day for 10 days. It works by eliminating the bacteria that cause many kinds of infections. This site needs JavaScript to work properly. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. They can let you know whether the medications are safe to take with G6PD deficiency. Observations of leukocytes obtained from patients treated with sulfamethoxazole and trimethoprim revealed no chromosomal abnormalities. However, for those who question absolutely everything, like myself, my tattoo is looking and doing good. Cipro (ciprofloxacin) and Levaquin (levofloxacin) are two popular medications in this group. Amber Yates, MD, is a board-certified pediatric hematologist and a practicing physician at Baylor College of Medicine. In these cases, benzyl alcohol dosages of 99 to 234 mg/kg/day produced high levels of benzyl alcohol and its metabolites in the blood and urine (blood levels of benzyl alcohol were 0.61 to 1.378 mmol/L). Once youre off the medication, wait six months to a year for it to be out of your system, and then it's safe for you to get inked. They can tell you what's safe to take. These studies, however, were limited by the small number of exposed cases and the lack of adjustment for multiple statistical comparisons and confounders. Weighing 80 kilograms (kg)10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. But I'm sure you keep your ink clean during healing anyway. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever the solution and container permit. UpToDate Upsides Your doctor may adjust this dose if needed. RxList does not provide medical advice, diagnosis or treatment. Speak to your doctor about how drug interactions should be managed. It seemed to be missing beats and stopping at times. Patients should follow their doctor's instructions and take all of the Bactrim prescribed. Healthline Media does not provide medical advice, diagnosis, or treatment. The following infusion systems have been tested and found satisfactory: unit-dose glass containers; unit-dose polyvinyl chloride and polyolefin containers. To make sure you can safely take Bactrim, tell your doctor if you have ever had: an electrolyte imbalance (such as low blood sodium or high potassium); porphyria, or glucose-6-phosphate dehydrogenase (G6PD) deficiency; or. In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. Aquaphor for Tattoos: Is This Recommended for Aftercare? - Healthline J Infect Dis. Accessibility For specific information regarding susceptibility test interpretive criteria, and associated test methods and quality control standards recognized by FDA for this drug, please see https://www.fda.gov/STIC. Drug information provided by: Merative, Micromedex. Persistent, sometimes itchy, and painful bumps in your tattoo may be signs of an atypical mycobacterial infection. We comply with the HONcode standard for trustworthy health information. LeBlanc PM, et al. In some rabbit studies, an overall increase in fetal loss (dead and resorbed conceptuses) was associated with doses of trimethoprim 6 times the human therapeutic dose based on body surface area. All rights reserved. ive missed three doses. What Type of Cancer Causes Low Hemoglobin (Anemia)? It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory . High potassium levels: nausea, muscle cramps or weakness. Suvanasuthi S, Wongpraparut C, Pattanaprichakul P, Bunyaratavej S. Nagore E, Ramos P, Botella-Estrada R, Ramos-Nguez JA, Sanmartn O, Castejn P. Acta Derm Venereol. These studies are further limited by recall, selection, and information biases, and by limited generalizability of their findings. Oct 1988;44(4):467-77. They are often used to treat urinary tract infections (UTIs) and pneumonia in adults. In vitro reverse mutation bacterial tests according to the standard protocol have not been performed with sulfamethoxazole and trimethoprim in combination. If your dose is different, do not change it unless your doctor tells you to do so. Buy Bactrim Pills Online - Sulfamethoxazole Bethesda, MD 20894, Web Policies There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. sore throat. Many people with G6PD deficiency don't experience any symptoms at all on a daily basis. Alternatively, other epidemiologic studies did not detect statistically significant associations between BACTRIM exposure and specific malformations. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. This practice includes employing preventative measures like wearing gloves and other protective gear and extends to avoiding contact with the client's body fluids. Naphthalene is a vapor (gas) given off by these products. Seek urgent medical advice if an unexplained cough, shortness of breath, sore throat, fever, muscle or joint pain, paleness or yellowing of the skin, or diarrhea develops. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Read our, Understanding the Many Types of Hemolytic Anemia. We report an uncommon case of a cutaneous infection with Mycobacterium fortuitum arising in a new tattoo. The following serious adverse reactions are described elsewhere in the labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. There are reported cases of henna triggering hemolytic crises in people with G6PD deficiency. Created for people with ongoing healthcare needs but benefits everyone. Kluger N. Contraindications for tattooing. 2007 Nov;29(11):1061-4. doi: 10.1002/hed.20626. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter. How long does it take for a boil to heal while taking Bactrim? Dermatol Online J. PMC 2023 Dotdash Media, Inc. All rights reserved. Bactrim is made up of two drugs: sulfamethoxazole and trimethoprim. Mothballs contain a chemical called naphthalene. These doses are approximately 5 and 6 times the recommended human total daily dose on a body surface area basis. Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. C. difficile produces toxins A and B which contribute to the development of CDAD. And those tiny openings on your skin make for perfect entry points for germs, bacteria, viruses, and other pathogens. Perform urinalyses with careful microscopic examination and renal function tests during therapy, particularly for those patients with impaired renal function. Common simple SSTIs include cellulitis, erysipelas, impetigo . . When administered together as BACTRIM, neither trimethoprim nor sulfamethoxazole affects the urinary excretion pattern of the other. Histopathologic examination revealed perifollicular chronic and granulomatous inflammation, consistent with chronic folliculitis. Advise female patients of reproductive potential that BACTRIM can cause fetal harm and to inform their healthcare provider of a known or suspected pregnancy [see Use In Specific Populations]. BACTRIM is contraindicated in pediatric patients less than two months of age [see CONTRAINDICATIONS]. Although appropriate culture and susceptibility studies should be performed, therapy may be started while awaiting the results of these studies. The .gov means its official. Copyright: Merative US L.P. 1973, 2023. But it's important to know that aspirin is also in many over-the-counter medicines, including: Looking for alternatives for pain relief doesnt have to be difficult, though. Sulfamethoxazole And Trimethoprim (Oral Route) - Mayo Clinic Do NOT mix Bactrim in 5% dextrose in water with drugs or solutions in the same container. Eveleth R. (2012). sulfamethoxazole and 160 mg trimethoprim b.i.d., the mean steady-state plasma concentration of trimethoprim was 1.72 g/mL. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. All of these 11 patients had normal renal function, and their ages ranged from 17 to 78 years (median, 60 years).11, Pharmacokinetic studies in children and adults suggest an age-dependent half-life of trimethoprim, as indicated in Table 5.12, Table 5: Half-life of Trimethoprim (TMP) in Pediatric Patients and Adults. This reaction is frequently dose-related. The good news? (n.d.). They recommend testing people for G6PD deficiency before they take primaquine. The mean maximum serum trimethoprim concentration was higher and mean renal clearance of trimethoprim was lower in geriatric subjects compared with younger subjects [see CLINICAL PHARMACOLOGY]. Sulfamethoxazole is an inhibitor of CYP2C9. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. 1996-2023 RxList, Inc. An Internet Brands company. These effects are reversible by folinic acid therapy. G6PD is an important enzyme (protein) in your body that protects your red blood cells from damage. In vitro studies suggest that trimethoprim is a substrate of P-glycoprotein, OCT1 and OCT2, and that sulfamethoxazole is not a substrate of P-glycoprotein. Urinary tract infection in pregnancy is associated with adverse perinatal outcomes such as preterm birth, low birth weight, and pre-eclampsia, and increased mortality to the pregnant woman. You should also avoid "quinolone" antibiotics. Bactrim vs. Keflex for Bacterial Infections: Differences - RxList Click here for an email preview. After initial entry into the vial, the remaining contents must be used within 48 hours. BACTRIM-induced thrombocytopenia may be an immune-mediated disorder. Keep in mind, however, that there will always be someone out there willing to take your money regardless of your health. These ingredients work. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bactrim only for the indication prescribed. The formulation of N 4-hydroxy metabolite is mediated via CYP2C9. Therefore, BACTRIM will not prevent sequelae such as rheumatic fever. Bactrim belongs to the class of medicines known as antibiotics. Low blood sodium levels: nausea, fatigue, headache, confusion, disoriented, hallucinations (seeing things that aren't real), seizures, unconsciousness. Copyright 1996-2023 Cerner Multum, Inc. 2001;85(5):411412. Weighing 40 kg5 teaspoonfuls (25 mL) or 2 tablets 4 times a day for 14 to 21 days. Don't go to someone you know uses unsafe practices because nobody safe will give you one. Read our, Prescription Medications to Disclose Before Getting a Tattoo. Bactrim Uses, Dosage & Side Effects - Drugs.com Certain antibiotic, anti-inflammatory, and anti-malarial medications can trigger red blood cell breakdown. Curr Probl Dermatol. Antimicrob Agents Chemother. The presence of BACTRIM may also interfere with the Jaffe alkaline picrate reaction assay for creatinine, resulting in overestimations of about 10% in the range of normal values. include protected health information. Bactrim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The free forms of trimethoprim and sulfamethoxazole are considered to be the therapeutically active forms. There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. the unsubscribe link in the e-mail. Like other drugs containing sulfonamides, BACTRIM can precipitate porphyria crisis and hypothyroidism. The hidden dangers of getting inked. include protected health information. Other over-the-counter pain relievers like acetaminophen or ibuprofen don't cause issues with G6PD. CDC links rare bacterial infection to tattoos. Weighing 64 kg8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. It is an almost white, odorless, tasteless compound with a molecular weight of 253.28 and the following structural formula: BACTRIM is indicated in the treatment of Pneumocystis jirovecii pneumonia in adults and pediatric patients two months of age and older. DOI: Mekaru S. (2011). See your doctor if you experience one or more of the following: A staph infection is one type of infection you might get with a tattoo. Although these infections are treatable, staph bacteria can often develop resistance to regular antibiotics, making prescription treatments ineffective. privacy practices. Clinical Pharmacology of Intravenously Administered Trimethoprim-Sulfamethoxazole. Staph infections are also common on fresh tattoos and may start showing signs as soon as after 2 days. If a significant blood dyscrasia or jaundice occurs, specific therapy should be instituted for these complications. Copyright 2023 by RxList Inc. An Internet Brands company. Cases of hypoglycemia in non-diabetic patients treated with BACTRIM have been seen, usually occurring after a few days of therapy. Advise patients that diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. If you miss a dose of this medicine, take it as soon as possible. if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests. the unsubscribe link in the e-mail. You should not use Bactrim if you have severe liver disease, kidney disease that is not being monitored, anemia caused by folic acid deficiency, if you take dofetilide, or if you have had low platelets caused by using trimethoprim or a sulfa drug. What to Do If Your New Tattoo Gets Infected - Good Housekeeping In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Avoid administration by rapid infusion or bolus injection. Non-tuberculous mycobacterium skin infections after tattooing in healthy individuals: A systematic review of case reports. Acute cellulitis and erysipelas in adults: Treatment. Active against a wide range of susceptible strains of gram-positive and gram-negative bacteria, such as. I was starting to panic. High dosage of trimethoprim, as used in patients with P. jirovecii pneumonia, induces a progressive but reversible increase of serum potassium concentrations in a substantial number of patients. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. The length of treatment may vary from 3 days to 14 days. Tattoo ink-related infections Awareness, diagnosis, reporting, and prevention. (twice a day). Mar 1979;15:447-451. * A total daily dose of 10 to 15 mg/kg was sufficient in 10 adult patients with normal renal function in a published literature. BACTRIM (sulfamethoxazole and trimethoprim) injection is supplied as follows: 10-mL Vials, containing 160 mg trimethoprim (16 mg/mL) and 800 mg sulfamethoxazole (80 mg/mL) for infusion with 5% dextrose in water. However, though rare, its possible to get a condition such as hepatitis or HIV from a tattoo needle. Current Chemotherapy and Infectious Diseases. My doc doesn't know if it would affect it or not. Do not double doses. I was unable to cut grass or do anything at all other than force myself to work each day. sharing sensitive information, make sure youre on a federal information is beneficial, we may combine your email and website usage information with Some people even take aspirin daily to prevent heart disease. Arthur C Huntley MD, California Digital Library. There are reported cases of henna . This monograph has been modified to include the generic and brand name in many instances. See additional information. Severe cases of thrombocytopenia that are fatal or life threatening have been reported. General principles of treatment include the administration of intravenous fluids if urine output is low and renal function is normal. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Rasburicase is a medicine used to treat tumor lysis syndrome. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Cipro (ciprofloxacin) and Levaquin (levofloxacin) are two popular medications in this group. Bactrim is available in tablets in two strengths; 400 mg sulfamethoxazole and 80 mg trimethoprim and the "DS" form which means double strength, 800 mg sulfamethoxazole and 160 mg trimethoprim. BACTRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. However, after normalizing by body weight, the apparent total body clearance of trimethoprim was on average 19% lower in geriatric subjects compared with young adult subjects. Thank you, {{form.email}}, for signing up. lower back or side pain. Anna Harris is an experienced fact-checker and researcher and a beauty writer and editor. 1 Karen L. Hudson is a tattoo artist and contributing writer for Byrdie. In vivo micronucleus assays were positive following oral administration of sulfamethoxazole/trimethoprim. 2003;289(16):2120-2127. The antibiotics didn't effect the healing process, or how it looked after it healed, like I was worried about. The maximum recommended daily dose is 60 mL (960 mg trimethoprim) per day. PDF BACTRIM sulfamethoxazole and trimethoprim PEDIATRIC SUSPENSION DESCRIPTION Reactions have included Stevens-Johnson syndrome (a disorder involving the skin and mucous membranes), liver disease, and blood disorders such as thrombocytopenia (low platelets). Sulfonamides can also displace methotrexate from plasma protein binding sites and can compete with the renal transport of methotrexate, thus increasing free methotrexate concentrations. Additional monitoring of blood glucose may be warranted. Life threatening hyperkalemia and acidosis secondary to trimethoprimsulfamethoxazole treatment. Bactrim contains a combination of sulfamethoxazole and trimethoprim. We'll discuss why. 1999;45:209- 212. This interaction should be kept in mind when BACTRIM is given to patients already on anticoagulant therapy, and the coagulation time should be reassessed. HHS Vulnerability Disclosure, Help Medically reviewed by Carmen Fookes, BPharm. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. (875 mg orally every 12 hours) plus either doxycycline (100 mg orally twice daily) or trimethoprim-sulfamethoxazole (TMP-SMX; one to two double-strength . Others only trigger problems in specific types of G6PD deficiency. Trimethoprim alone was negative in in vitro reverse mutation bacterial assays and in in vitro chromosomal aberration assays with Chinese Hamster ovary or lung cells with or without S9 activation. If you're not disclosing your medical conditions to your tattoo artist prior to your session, what your tattoo artist doesn't know could seriously harm you. Last reviewed on RxList: 11/25/2020 Children 2 months of age and olderUse and dose must be determined by your doctor. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Distributed by: Sun Pharmaceutical Industries, Inc. Cranbury, NJ 08512. MisterBearcat 8 yr. ago Consult with your doctor first to determine if your overall health is strong enough to withstand the stress of getting tattooed and if your medications may interfere with the healing process. Monitor for the total daily intake of propylene glycol from all sources and for acid-base disturbances. Over The Counter Antibiotics For Infected Tattoo - TattooTalk.net Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. FOIA BACTRIM is a combination of sulfamethoxazole, a sulfonamide antimicrobial, and trimethoprim, a dihydrofolate reductase inhibitor antibacterial, indicated in adults and pediatric patients two months of age and older for treatment of infections caused by designated, susceptible bacteria. Do not refrigerate. Think before you ink: Are tattoos safe? information submitted for this request. Al-Khatib SM, LaPointe N, Kramer JM, Califf RM. . The incidence of adverse reactions, particularly rash, fever, leukopenia, and elevated aminotransferase (transaminase) values, with BACTRIM therapy in AIDS patients who are being treated for Pneumocystis jirovecii pneumonia has been reported to be greatly increased compared with the incidence normally associated with the use of BACTRIM in non-AIDS patients.